Histone H3K27 trimethylation modulates 5-fluorouracil resistance by inhibiting PU.1 binding to the DPYD promoter

The antimetabolite 5-fluorouracil (5-FU) is one of the most widely used chemotherapy drugs. Dihydropyrimidine dehydrogenase (DPD) is a major determinant of 5-FU response and toxicity. While DPYD variants may affect 5-FU metabolism, they do not completely explain the reported variability in DPD funct...

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發表在:Cancer Res
Main Authors: Wu, Rentian, Nie, Qian, Tapper, Erin E., Jerde, Calvin R., Dunlap, Garrett S., Shrestha, Shikshya, Elraiyah, Tarig A., Offer, Steven M., Diasio, Robert B.
格式: Artigo
語言:Inglês
出版: 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5093042/
https://ncbi.nlm.nih.gov/pubmed/27578004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-1306
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