Novel deleterious dihydropyrimidine dehydrogenase variants may contribute to 5-fluorouracil sensitivity in an East African population

Clinical studies have identified specific genetic variants in dihydropyrimidine dehydrogenase (DPD, DPYD gene) as predictors of severe adverse toxicity to the commonly used chemotherapeutic 5-fluorouracil; however, these studies have focused on European and European-American populations. Our lab rec...

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Vydáno v:Clin Pharmacol Ther
Hlavní autoři: Elraiyah, Tarig, Jerde, Calvin R., Shrestha, Shikshya, Wu, Rentian, Nie, Qian, Giama, Nasra H., Sarangi, Vivekananda, Roberts, Lewis R., Offer, Steven M., Diasio, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5309195/
https://ncbi.nlm.nih.gov/pubmed/27727460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.531
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