A behavioral test battery for mouse models of Angelman syndrome: a powerful tool for testing drugs and novel Ube3a mutants

BACKGROUND: Angelman syndrome (AS) is a neurodevelopmental disorder caused by mutations affecting UBE3A function. AS is characterized by intellectual disability, impaired motor coordination, epilepsy, and behavioral abnormalities including autism spectrum disorder features. The development of treatm...

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Vydáno v:Mol Autism
Hlavní autoři: Sonzogni, Monica, Wallaard, Ilse, Santos, Sara Silva, Kingma, Jenina, du Mee, Dorine, van Woerden, Geeske M., Elgersma, Ype
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137919/
https://ncbi.nlm.nih.gov/pubmed/30220990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-018-0231-7
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