In silico Prioritization of Transporter–Drug Relationships From Drug Sensitivity Screens

The interplay between drugs and cell metabolism is a key factor in determining both compound potency and toxicity. In particular, how and to what extent transmembrane transporters affect drug uptake and disposition is currently only partially understood. Most transporter proteins belong to two prote...

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Publicat a:Front Pharmacol
Autors principals: César-Razquin, Adrián, Girardi, Enrico, Yang, Mi, Brehme, Marc, Saez-Rodriguez, Julio, Superti-Furga, Giulio
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6137680/
https://ncbi.nlm.nih.gov/pubmed/30245630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.01011
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