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NAD(+) Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a secreted nicotinamide adenine dinucleotide (NAD(+)) glycohydrolase that induces necrosis in infected macrophages. Here, we show that NAD(+) deplet...
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| Pubblicato in: | Cell Rep |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6136256/ https://ncbi.nlm.nih.gov/pubmed/29996103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.042 |
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