NAD(+) Depletion Triggers Macrophage Necroptosis, a Cell Death Pathway Exploited by Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb) kills infected macrophages by inhibiting apoptosis and promoting necrosis. The tuberculosis necrotizing toxin (TNT) is a secreted nicotinamide adenine dinucleotide (NAD(+)) glycohydrolase that induces necrosis in infected macrophages. Here, we show that NAD(+) deplet...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Cell Rep
Autori principali: Pajuelo, David, Gonzalez-Juarbe, Norberto, Tak, Uday, Sun, Jim, Orihuela, Carlos J., Niederweis, Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6136256/
https://ncbi.nlm.nih.gov/pubmed/29996103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.06.042
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi