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The Tuberculosis Necrotizing Toxin kills macrophages by hydrolyzing NAD
Mycobacterium tuberculosis (Mtb) induces necrosis of infected cells to evade immune responses. Recently, we found that Mtb utilizes the protein CpnT to kill human macrophages by secreting its C-terminal domain, named tuberculosis necrotizing toxin (TNT) that induces necrosis by an unknown mechanism....
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| Publicat a: | Nat Struct Mol Biol |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4560639/ https://ncbi.nlm.nih.gov/pubmed/26237511 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3064 |
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