Stable isotope‐labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

BACKGROUND AND PURPOSE: Chronic administration of medication can significantly affect metabolic enzymes leading to physiological adaptations. Morphine metabolism in the liver has been extensively studied following acute morphine treatment, but such metabolic processes in the CNS are poorly character...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Weinsanto, Ivan, Laux‐Biehlmann, Alexis, Mouheiche, Jinane, Maduna, Tando, Delalande, François, Chavant, Virginie, Gabel, Florian, Darbon, Pascal, Charlet, Alexandre, Poisbeau, Pierrick, Lamshöft, Marc, Van Dorsselaer, Alain, Cianferani, Sarah, Parat, Marie‐Odile, Goumon, Yannick
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135784/
https://ncbi.nlm.nih.gov/pubmed/30051501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14454
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