Stable isotope‐labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

BACKGROUND AND PURPOSE: Chronic administration of medication can significantly affect metabolic enzymes leading to physiological adaptations. Morphine metabolism in the liver has been extensively studied following acute morphine treatment, but such metabolic processes in the CNS are poorly character...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Weinsanto, Ivan, Laux‐Biehlmann, Alexis, Mouheiche, Jinane, Maduna, Tando, Delalande, François, Chavant, Virginie, Gabel, Florian, Darbon, Pascal, Charlet, Alexandre, Poisbeau, Pierrick, Lamshöft, Marc, Van Dorsselaer, Alain, Cianferani, Sarah, Parat, Marie‐Odile, Goumon, Yannick
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2018
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135784/
https://ncbi.nlm.nih.gov/pubmed/30051501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14454
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