Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo

Background: Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the same UDP-glucuronosy...

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Detalles Bibliográficos
Publicado en:Front Oncol
Main Authors: Gabel, Florian, Aubry, Anne-Sophie, Hovhannisyan, Volodya, Chavant, Virginie, Weinsanto, Ivan, Maduna, Tando, Darbon, Pascal, Goumon, Yannick
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2020
Assuntos:
Oncology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046683/
https://ncbi.nlm.nih.gov/pubmed/32154159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2020.00025
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