Stable isotope‐labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice

BACKGROUND AND PURPOSE: Chronic administration of medication can significantly affect metabolic enzymes leading to physiological adaptations. Morphine metabolism in the liver has been extensively studied following acute morphine treatment, but such metabolic processes in the CNS are poorly character...

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Dades bibliogràfiques
Publicat a:Br J Pharmacol
Autors principals: Weinsanto, Ivan, Laux‐Biehlmann, Alexis, Mouheiche, Jinane, Maduna, Tando, Delalande, François, Chavant, Virginie, Gabel, Florian, Darbon, Pascal, Charlet, Alexandre, Poisbeau, Pierrick, Lamshöft, Marc, Van Dorsselaer, Alain, Cianferani, Sarah, Parat, Marie‐Odile, Goumon, Yannick
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135784/
https://ncbi.nlm.nih.gov/pubmed/30051501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14454
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