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Independent Generation of Reactive Intermediates Leads to an Alternative Mechanism for Strand Damage Induced by Hole Transfer in Poly(dA-T) Sequences

Purine radical cations (dA•+ and dG•+) are the primary hole carriers of DNA hole migration owing to their favorable oxidation potential. Much less is known about the reactivity of higher energy pyrimidine radical cations. The thymidine radical cation (T•+) was produced at a defined position in DNA f...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Sun, Huabing, Zheng, Liwei, Greenberg, Marc M.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135700/
https://ncbi.nlm.nih.gov/pubmed/30169029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b05484
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