PTENα regulates mitophagy and maintains mitochondrial quality control

PTEN plays an important role in tumor suppression, and PTEN family members are involved in multiple biological processes in various subcellular locations. Here we report that PTENα, the first identified PTEN isoform, regulates mitophagy through promotion of PARK2 recruitment to damaged mitochondria....

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Li, Guoliang, Yang, Jingyi, Yang, Chunyuan, Zhu, Minglu, Jin, Yan, McNutt, Michael A., Yin, Yuxin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
Soggetti:
Research Paper - Basic Science
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135630/
https://ncbi.nlm.nih.gov/pubmed/29969932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1489477
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