PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function

PTEN is one of the most frequently mutated genes in human cancer. It is known that PTEN has a wide range of biological functions beyond tumor suppression. Here we report that PTENα, an N-terminally extended form of PTEN, functions in metabolism. Translation of PTENα is initiated from a CUG codon ups...

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Detalhes bibliográficos
Main Authors: Liang, Hui, He, Shiming, Yang, Jingyi, Jia, Xinying, Wang, Pan, Chen, Xi, Zhang, Zhong, Zou, Xiajuan, McNutt, Michael A., Shen, Wen Hong, Yin, Yuxin
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4097321/
https://ncbi.nlm.nih.gov/pubmed/24768297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.03.023
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