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Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply

Normal metabolism requires a controlled balance between anabolism and catabolism. It is not completely known how this balance can be retained when the level of nutrient supply changes in the long term. We found that in murine liver anabolism, as represented by the phosphorylation of RPS6KB (ribosoma...

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Dettagli Bibliografici
Pubblicato in:Autophagy
Autori principali: Zhang, Hao, Yan, Shengmin, Khambu, Bilon, Ma, Fengguang, Li, Yong, Chen, Xiaoyun, Martina, Jose. A., Puertollano, Rosa, Li, Yu, Chalasani, Naga, Yin, Xiao-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6135624/
https://ncbi.nlm.nih.gov/pubmed/30044707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1490850
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