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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
The mammalian target of rapamycin (MTOR) protein kinase complex is a key component of a pathway that regulates cell growth and proliferation in response to energy levels, hypoxia, nutrients and insulin. Inhibition of MTORC1 strongly induces autophagy by regulating the activity of the ULK protein kin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Landes Bioscience
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3427256/ https://ncbi.nlm.nih.gov/pubmed/22576015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.19653 |
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