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TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis
TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces apoptosis, patients with TRIM37 mutations have a high risk of developing tumors, suggesting that there may be an alternative pro-survival mec...
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| Publicado no: | Autophagy |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6135569/ https://ncbi.nlm.nih.gov/pubmed/29940807 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2018.1463120 |
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