Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells

OBJECTIVE: IL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and generally acts as an activating signal. H...

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Bibliografiska uppgifter
I publikationen:Inflamm Res
Huvudupphovsmän: Ono, Hiroaki, Ohta, Ryo, Kawasaki, Yuri, Niwa, Akira, Takada, Hidetoshi, Nakahata, Tatsutoshi, Ohga, Shouichi, Saito, Megumu K.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer International Publishing 2018
Ämnen:
Original Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6133165/
https://ncbi.nlm.nih.gov/pubmed/30136196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00011-018-1178-z
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