Pluripotent stem cell model of early hematopoiesis in Down syndrome reveals quantitative effects of short-form GATA1 protein on lineage specification

Children with Down syndrome (DS) are susceptible to two blood disorders, transient abnormal myelopoiesis (TAM) and Down syndrome-associated acute megakaryocytic leukemia (DS-AMKL). Mutations in GATA binding protein 1 (GATA1) have been identified as the cause of these diseases, and the expression lev...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Matsuo, Shiori, Nishinaka-Arai, Yoko, Kazuki, Yasuhiro, Oshimura, Mitsuo, Nakahata, Tatsutoshi, Niwa, Akira, Saito, Megumu K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8007000/
https://ncbi.nlm.nih.gov/pubmed/33780474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0247595
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