Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity

Curative therapeutic options for a number of immunological disorders remain to be established, and approaches for identifying drug candidates are relatively limited. Furthermore, phenotypic screening methods using induced pluripotent stem cell (iPSC)-derived immune cells or hematopoietic cells need...

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Veröffentlicht in:PLoS One
Hauptverfasser: Seki, Ryosuke, Ohta, Akira, Niwa, Akira, Sugimine, Yoshinori, Naito, Haruna, Nakahata, Tatsutoshi, Saito, Megumu K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7437452/
https://ncbi.nlm.nih.gov/pubmed/32810141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237030
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