Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

Safety assessment of drug candidates in numerous in vitro and experimental animal models is expensive, time consuming and animal intensive. More thorough toxicity profiling already in the early drug discovery projects using human cell models, which more closely resemble the physiological cell types,...

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Bibliografiska uppgifter
I publikationen:Arch Toxicol
Huvudupphovsmän: Karhu, S. Tuuli, Välimäki, Mika J., Jumppanen, Mikael, Kinnunen, Sini M., Pohjolainen, Lotta, Leigh, Robert S., Auno, Samuli, Földes, Gábor, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Ruskoaho, Heikki, Talman, Virpi
Materialtyp: Artigo
Språk:Inglês
Publicerad: Springer Berlin Heidelberg 2018
Ämnen:
In Vitro Systems
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132687/
https://ncbi.nlm.nih.gov/pubmed/29987409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2257-1
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