Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

Safety assessment of drug candidates in numerous in vitro and experimental animal models is expensive, time consuming and animal intensive. More thorough toxicity profiling already in the early drug discovery projects using human cell models, which more closely resemble the physiological cell types,...

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Bibliografske podrobnosti
izdano v:Arch Toxicol
Main Authors: Karhu, S. Tuuli, Välimäki, Mika J., Jumppanen, Mikael, Kinnunen, Sini M., Pohjolainen, Lotta, Leigh, Robert S., Auno, Samuli, Földes, Gábor, Boije af Gennäs, Gustav, Yli-Kauhaluoma, Jari, Ruskoaho, Heikki, Talman, Virpi
Format: Artigo
Jezik:Inglês
Izdano: Springer Berlin Heidelberg 2018
Teme:
In Vitro Systems
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6132687/
https://ncbi.nlm.nih.gov/pubmed/29987409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-018-2257-1
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