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Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2-5 Protein–Protein Interaction Modulators

[Image: see text] Transcription factors GATA4 and NKX2-5 directly interact and synergistically activate several cardiac genes and stretch-induced cardiomyocyte hypertrophy. Previously, we identified phenylisoxazole carboxamide 1 as a hit compound, which inhibited the GATA4–NKX2-5 transcriptional syn...

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Vydáno v:J Med Chem
Hlavní autoři: Jumppanen, Mikael, Kinnunen, Sini M., Välimäki, Mika J., Talman, Virpi, Auno, Samuli, Bruun, Tanja, Boije af Gennäs, Gustav, Xhaard, Henri, Aumüller, Ingo B., Ruskoaho, Heikki, Yli-Kauhaluoma, Jari
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2019
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7076710/
https://ncbi.nlm.nih.gov/pubmed/31431011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01086
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