GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

Doxorubicin is a widely used anticancer drug that causes dose-related cardiotoxicity. The exact mechanisms of doxorubicin toxicity are still unclear, partly because most in vitro studies have evaluated the effects of short-term high-dose doxorubicin treatments. Here, we developed an in vitro model o...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Arch Toxicol
Egile Nagusiak: Karhu, S. Tuuli, Kinnunen, Sini M., Tölli, Marja, Välimäki, Mika J., Szabó, Zoltán, Talman, Virpi, Ruskoaho, Heikki
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Springer Berlin Heidelberg 2020
Gaiak:
Organ Toxicity and Mechanisms
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7303099/
https://ncbi.nlm.nih.gov/pubmed/32185414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-020-02711-8
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