Ectopic expression of aPKC-mediated phosphorylation in p300 modulates hippocampal neurogenesis, CREB binding and fear memory differently with age

Epigenetic modifications have become an emerging interface that links extrinsic signals to alterations of gene expression that determine cell identity and function. However, direct signaling that regulates epigenetic modifications is unknown. Our previous work demonstrated that phosphorylation of CB...

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Udgivet i:Sci Rep
Main Authors: Syal, Charvi, Seegobin, Matthew, Sarma, Sailendra Nath, Gouveia, Ayden, Hsu, Karolynn, Niibori, Yosuke, He, Ling, Wondisford, Fredric E., Frankland, Paul W., Wang, Jing
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131509/
https://ncbi.nlm.nih.gov/pubmed/30201979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31657-2
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