Dysregulated expression of monoacylglycerol lipase is a marker for anti-diabetic drug metformin-targeted therapy to correct impaired neurogenesis and spatial memory in Alzheimer's disease

Rationale: Monoacylglycerol lipase (Mgll), a hydrolase that breaks down the endocannabinoid 2-arachidonoyl glycerol (2-AG) to produce arachidonic acid (ARA), is a potential target for neurodegenerative diseases, such as Alzheimer's disease (AD). Increasing evidence shows that impairment of adul...

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Detalhes bibliográficos
Publicado no:Theranostics
Main Authors: Syal, Charvi, Kosaraju, Jayasankar, Hamilton, Laura, Aumont, Anne, Chu, Alphonse, Sarma, Sailendra Nath, Thomas, Jacob, Seegobin, Matthew, Dilworth, F Jeffrey, He, Ling, Wondisford, Fredric E, Zimmermann, Robert, Parent, Martin, Fernandes, Karl, Wang, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2020
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7255032/
https://ncbi.nlm.nih.gov/pubmed/32483456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.44962
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