Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin

The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated. The aim of our study was to investigate the relevance of copper transporters (CTR1 and ATP7A/B), organic cation transporters (OCT2) and the mul...

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Detalhes bibliográficos
Publicado no:Front Chem
Main Authors: Spreckelmeyer, Sarah, van der Zee, Margot, Bertrand, Benoît, Bodio, Ewen, Stürup, Stefan, Casini, Angela
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Chemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131305/
https://ncbi.nlm.nih.gov/pubmed/30234099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2018.00377
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