Cyclometalated Iminophosphorane Gold(III) and Platinum(II) Complexes. A Highly Permeable Cationic Platinum(II) Compound with Promising Anticancer Properties

[Image: see text] New organometallic gold(III) and platinum(II) complexes containing iminophosphorane ligands are described. Most of them are more cytotoxic to a number of human cancer cell lines than cisplatin. Cationic Pt(II) derivatives 4 and 5, which differ only in the anion, Hg(2)Cl(6)(2–) or P...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Frik, Malgorzata, Fernández-Gallardo, Jacob, Gonzalo, Oscar, Mangas-Sanjuan, Víctor, González-Alvarez, Marta, Serrano del Valle, Alfonso, Hu, Chunhua, González-Alvarez, Isabel, Bermejo, Marival, Marzo, Isabel, Contel, María
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538566/
https://ncbi.nlm.nih.gov/pubmed/26147404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00427
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