Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma

RAS mutations are frequent in relapsed/refractory multiple myeloma (RRMM) but functional study in primary samples is scanty. Herein, in primary myeloma plasma cells of 17 suspected RRMM, functional activation of RAS signalling was studied by Western blot of phosphorylated ERK1/2 (phospho-ERK1/2). Mo...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Wong, Kwan Yeung, Yao, Qiumei, Yuan, Ling-Qing, Li, Zhenhai, Ma, Edmond Shiu Kwan, Chim, Chor Sang
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131153/
https://ncbi.nlm.nih.gov/pubmed/30201956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-31820-9
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