Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Zhang, Cai, Seo, Joonbae, Murakami, Kazutoshi, Salem, Esam S. B., Bernhard, Elise, Borra, Vishnupriya J., Choi, Kwangmin, Yuan, Celvie L., Chan, Calvin C., Chen, Xiaoting, Huang, Taosheng, Weirauch, Matthew T., Divanovic, Senad, Qi, Nathan R., Thomas, Hala Einakat, Mercer, Carol A., Siomi, Haruhiko, Nakamura, Takahisa
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2018
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131149/
https://ncbi.nlm.nih.gov/pubmed/30201950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05870-6
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