Hepatic Ago2-mediated RNA silencing controls energy metabolism linked to AMPK activation and obesity-associated pathophysiology

RNA silencing inhibits mRNA translation. While mRNA translation accounts for the majority of cellular energy expenditure, it is unclear if RNA silencing regulates energy homeostasis. Here, we report that hepatic Argonaute 2 (Ago2)-mediated RNA silencing regulates both intrinsic energy production and...

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Publicado no:Nat Commun
Main Authors: Zhang, Cai, Seo, Joonbae, Murakami, Kazutoshi, Salem, Esam S. B., Bernhard, Elise, Borra, Vishnupriya J., Choi, Kwangmin, Yuan, Celvie L., Chan, Calvin C., Chen, Xiaoting, Huang, Taosheng, Weirauch, Matthew T., Divanovic, Senad, Qi, Nathan R., Thomas, Hala Einakat, Mercer, Carol A., Siomi, Haruhiko, Nakamura, Takahisa
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6131149/
https://ncbi.nlm.nih.gov/pubmed/30201950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-05870-6
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