Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically-defined regu...

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發表在:Nat Med
Main Authors: Patten, Darren K., Corleone, Giacomo, Győrffy, Balázs, Perone, Ylenia, Slaven, Neil, Barozzi, Iros, Erdős, Edina, Saiakhova, Alina, Goddard, Kate, Vingiani, Andrea, Shousha, Sami, Pongor, Lőrinc Sándor, Hadjiminas, Dimitri J., Schiavon, Gaia, Barry, Peter, Palmieri, Carlo, Coombes, Raul C., Scacheri, Peter, Pruneri, Giancarlo, Magnani, Luca
格式: Artigo
語言:Inglês
出版: 2018
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130800/
https://ncbi.nlm.nih.gov/pubmed/30038216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0091-x
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