Enhancer mapping uncovers phenotypic heterogeneity and evolution in patients with luminal breast cancer

The degree of intrinsic and interpatient phenotypic heterogeneity and its role in tumour evolution is poorly understood. Phenotypic drifts can be transmitted via inheritable transcriptional programs. Cell-type specific transcription is maintained through the activation of epigenetically-defined regu...

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Publicado en:Nat Med
Autores principales: Patten, Darren K., Corleone, Giacomo, Győrffy, Balázs, Perone, Ylenia, Slaven, Neil, Barozzi, Iros, Erdős, Edina, Saiakhova, Alina, Goddard, Kate, Vingiani, Andrea, Shousha, Sami, Pongor, Lőrinc Sándor, Hadjiminas, Dimitri J., Schiavon, Gaia, Barry, Peter, Palmieri, Carlo, Coombes, Raul C., Scacheri, Peter, Pruneri, Giancarlo, Magnani, Luca
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130800/
https://ncbi.nlm.nih.gov/pubmed/30038216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0091-x
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