Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

A variety of innate immune responses and functions are dependent on time of day, and many inflammatory conditions are associated with dysfunctional molecular clocks within immune cells. However, the functional importance of these innate immune clocks has yet to be fully characterized. NRF2 plays a c...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Early, James O., Menon, Deepthi, Wyse, Cathy A., Cervantes-Silva, Mariana P., Zaslona, Zbigniew, Carroll, Richard G., Palsson-McDermott, Eva M., Angiari, Stefano, Ryan, Dylan G., Corcoran, Sarah E., Timmons, George, Geiger, Sarah S., Fitzpatrick, Darren J., O’Connell, Daniel, Xavier, Ramnik J., Hokamp, Karsten, O’Neill, Luke A. J., Curtis, Annie M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6130388/
https://ncbi.nlm.nih.gov/pubmed/30127006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1800431115
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