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Theory of Site-Specific DNA-Protein Interactions in the Presence of Nucleosome Roadblocks
We show that nucleosomes exert a maximal amount of hindrance to the one-dimensional diffusion of transcription factors (TFs) when they are present between TFs and their cognate sites on DNA. The effective one-dimensional diffusion coefficient of TFs (χ(TF)) decreases with a rise in the free-energy b...
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| Publicado no: | Biophys J |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6129559/ https://ncbi.nlm.nih.gov/pubmed/29874603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.04.039 |
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