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Theory of Site-Specific DNA-Protein Interactions in the Presence of Conformational Fluctuations of DNA Binding Domains
We develop a theory that explains how the thermally driven conformational fluctuations in the DNA binding domains (DBDs) of the DNA binding proteins (DBPs) are effectively coupled to the one-dimensional searching dynamics of DBPs for their cognate sites on DNA. We show that the rate γ(opt), associat...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2905069/ https://ncbi.nlm.nih.gov/pubmed/20643052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2010.04.026 |
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