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IL-10 induces an immune repressor pathway in sepsis by promoting S100A9 nuclear localization and MDSC development
The myeloid-related protein S100A9 reprograms Gr1(+)CD11b(+) myeloid precursors into myeloid- derived suppressor cells (MDSCs) during murine sepsis. Here, we show that the immunosuppressive cytokine IL-10 supports S100A9 expression and its nuclear localization in MDSCs to function as immune represso...
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| Publicado no: | Cell Immunol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6129403/ https://ncbi.nlm.nih.gov/pubmed/30025864 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellimm.2018.07.003 |
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