METABOLISM OF MEGESTROL ACETATE IN VITRO AND THE ROLE OF OXIDATIVE METABOLITES

There is limited knowledge regarding the metabolism of megestrol acetate (MA), as it was approved by FDA in 1971, prior to the availability of modern tools for identifying specific drug-metabolizing enzymes. We determined the cytochrome P450s (P450s) and UDP-glucuronosyltransferases (UGTs) that meta...

詳細記述

保存先:
書誌詳細
出版年:Xenobiotica
主要な著者: House, Larry, Seminerio, Michael, Mirkov, Snezana, Ramirez, Jacqueline, Skor, Maxwell, Sachleben, Joseph, Isikbay, Masis, Singhal, Hari, Greene, Geoffrey, Griend, Donald Vander, Conzen, Suzanne, Ratain, Mark J
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129397/
https://ncbi.nlm.nih.gov/pubmed/29050522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1386335
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