METABOLISM OF MEGESTROL ACETATE IN VITRO AND THE ROLE OF OXIDATIVE METABOLITES

There is limited knowledge regarding the metabolism of megestrol acetate (MA), as it was approved by FDA in 1971, prior to the availability of modern tools for identifying specific drug-metabolizing enzymes. We determined the cytochrome P450s (P450s) and UDP-glucuronosyltransferases (UGTs) that meta...

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Bibliografiske detaljer
Udgivet i:Xenobiotica
Main Authors: House, Larry, Seminerio, Michael, Mirkov, Snezana, Ramirez, Jacqueline, Skor, Maxwell, Sachleben, Joseph, Isikbay, Masis, Singhal, Hari, Greene, Geoffrey, Griend, Donald Vander, Conzen, Suzanne, Ratain, Mark J
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129397/
https://ncbi.nlm.nih.gov/pubmed/29050522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2017.1386335
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