Development of a gut microbe-targeted non-lethal therapeutic to inhibit thrombosis potential

Trimethylamine-N-oxide (TMAO), a microbiota-dependent metabolite derived from trimethylamine (TMA)-containing nutrients that are abundant in a Western diet, enhances both platelet responsiveness and in vivo thrombosis potential in animal models and predicts incident atherothrombotic event risks in c...

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Publicado no:Nat Med
Main Authors: Roberts, Adam B., Gu, Xiaodong, Buffa, Jennifer A., Hurd, Alex G., Wang, Zeneng, Zhu, Weifei, Gupta, Nilaksh, Skye, Sarah M., Cody, David B., Levison, Bruce S., Barrington, William T., Russel, Matthew W., Reed, Jodie M., Duzan, Ashraf, Lang, Jennifer M., Fu, Xiaoming, Li, Lin, Myers, Alex J., Rachakonda, Suguna, DiDonato, Joseph A., Brown, J. Mark, Gogonea, Valentin, Lusis, Aldons J., Garcia-Garcia, Jose Carlos, Hazen, Stanley L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129214/
https://ncbi.nlm.nih.gov/pubmed/30082863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-018-0128-1
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