Dppa2/4 facilitate epigenetic remodeling during reprogramming to pluripotency

As somatic cells are converted into iPSCs, their chromatin is remodeled to a pluripotent configuration with unique euchromatin-to-heterochromatin ratio, DNA methylation patterns and enhancer/promoter status. The molecular machinery underlying this process is largely unknown. Here, we show that ESC-s...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Hernandez, Charles, Wang, Zheng, Ramazanov, Bulat, Tang, Yin, Mehta, Sameet, Dambrot, Cheryl, Lee, Yu-Wei, Tessema, Kaleab, Kumar, Ishan, Astudillo, Michael, Neubert, Thomas A., Guo, Shangqin, Ivanova, Natalia B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128737/
https://ncbi.nlm.nih.gov/pubmed/30146411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2018.08.001
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