Tdp1 processes chromate-induced single-strand DNA breaks that collapse replication forks

Hexavalent chromium [Cr(VI)] damages DNA and causes cancer, but it is unclear which DNA damage responses (DDRs) most critically protect cells from chromate toxicity. Here, genome-wide quantitative functional profiling, DDR measurements and genetic interaction assays in Schizosaccharomyces pombe reve...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Ganguly, Abantika, Guo, Lan, Sun, Lingling, Suo, Fang, Du, Li-Lin, Russell, Paul
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128646/
https://ncbi.nlm.nih.gov/pubmed/30148840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007595
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