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Triplex structures induce DNA double strand breaks via replication fork collapse in NER deficient cells
Structural alterations in DNA can serve as natural impediments to replication fork stability and progression, resulting in DNA damage and genomic instability. Naturally occurring polypurine mirror repeat sequences in the human genome can create endogenous triplex structures evoking a robust DNA dama...
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| Опубликовано в: : | Nucleic Acids Res |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5027492/ https://ncbi.nlm.nih.gov/pubmed/27298253 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw515 |
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