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Virtual screening using covalent docking to find activators for G245S mutant p53
TP53 is the most mutated gene in all cancers. The mutant protein also accumulates in cells. The high frequency of p53 mutations makes the protein a promising target for anti-cancer therapy. Only a few molecules have been found, using in vitro screening, to reactivate the mutant protein. APR-246 is c...
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| Publicat a: | PLoS One |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6128461/ https://ncbi.nlm.nih.gov/pubmed/30192754 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0200769 |
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