Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer proteins (PITPs) contributes to hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation. Conditional knockout mice lacking PITPs specifically in MKs and platelets (pi...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Capitano, Maegan, Zhao, Liang, Cooper, Scott, Thorsheim, Chelsea, Suzuki, Aae, Huang, Xinxin, Dent, Alexander L., Marks, Michael S., Abrams, Charles S., Broxmeyer, Hal E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2018
Assuntos:
Hematopoiesis and Stem Cells
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128088/
https://ncbi.nlm.nih.gov/pubmed/30042096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-806257
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