Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer proteins (PITPs) contributes to hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation. Conditional knockout mice lacking PITPs specifically in MKs and platelets (pi...

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Pubblicato in:Blood
Autori principali: Capitano, Maegan, Zhao, Liang, Cooper, Scott, Thorsheim, Chelsea, Suzuki, Aae, Huang, Xinxin, Dent, Alexander L., Marks, Michael S., Abrams, Charles S., Broxmeyer, Hal E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2018
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128088/
https://ncbi.nlm.nih.gov/pubmed/30042096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-806257
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