Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice

We hypothesized that megakaryocyte (MK) phosphoinositide signaling mediated by phosphatidylinositol transfer proteins (PITPs) contributes to hematopoietic stem cell (HSC) and hematopoietic progenitor cell (HPC) regulation. Conditional knockout mice lacking PITPs specifically in MKs and platelets (pi...

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Vydáno v:Blood
Hlavní autoři: Capitano, Maegan, Zhao, Liang, Cooper, Scott, Thorsheim, Chelsea, Suzuki, Aae, Huang, Xinxin, Dent, Alexander L., Marks, Michael S., Abrams, Charles S., Broxmeyer, Hal E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Hematopoiesis and Stem Cells
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6128088/
https://ncbi.nlm.nih.gov/pubmed/30042096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-806257
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