Combination of Asiatic Acid and Naringenin Modulates NK Cell Anti-cancer Immunity by Rebalancing Smad3/Smad7 Signaling

Transforming growth factor β1 (TGF-β1) plays a promoting role in tumor growth via a mechanism associated with hyperactive Smad3 and suppressed Smad7 signaling in the tumor microenvironment. We report that retrieving the balance between Smad3 and Smad7 signaling with asiatic acid (AA, a Smad7 inducer...

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Gepubliceerd in:Mol Ther
Hoofdauteurs: Lian, Guang-Yu, Wang, Qing-Ming, Tang, Patrick Ming-Kuen, Zhou, Shuang, Huang, Xiao-Ru, Lan, Hui-Yao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2018
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127879/
https://ncbi.nlm.nih.gov/pubmed/30017880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.06.016
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