Smad3 promotes cancer progression by inhibiting E4BP4-mediated NK cell development

TGF-β is known to influence tumour progression. Here we report an additional role of Smad3 in the tumour microenvironment regulating cancer progression. Deletion or inhibition of Smad3 in the tumour microenvironment suppresses tumour growth, invasion and metastasis in two syngeneic mouse tumour mode...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Tang, Patrick Ming-Kuen, Zhou, Shuang, Meng, Xiao-Ming, Wang, Qing-Ming, Li, Chun-Jie, Lian, Guang-Yu, Huang, Xiao-Ru, Tang, Yong-Jiang, Guan, Xin-Yuan, Yan, Bryan Ping-Yen, To, Ka-Fai, Lan, Hui-Yao
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5343519/
https://ncbi.nlm.nih.gov/pubmed/28262747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14677
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