Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

DNA damage can be sensed as a danger-associated molecular pattern by the innate immune system. Here we find that keratinocytes and other human cells mount an innate immune response within hours of etoposide-induced DNA damage, which involves the DNA sensing adaptor STING but is independent of the cy...

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Publicat a:Mol Cell
Autors principals: Dunphy, Gillian, Flannery, Sinéad M., Almine, Jessica F., Connolly, Dympna J., Paulus, Christina, Jønsson, Kasper L., Jakobsen, Martin R., Nevels, Michael M., Bowie, Andrew G., Unterholzner, Leonie
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127031/
https://ncbi.nlm.nih.gov/pubmed/30193098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.07.034
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