IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes

Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP). Other putative DNA receptors have been described, but whether their functions are redundant, tissue-...

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Vydáno v:Nat Commun
Hlavní autoři: Almine, Jessica F., O'Hare, Craig A. J., Dunphy, Gillian, Haga, Ismar R., Naik, Rangeetha J., Atrih, Abdelmadjid, Connolly, Dympna J., Taylor, Jordan, Kelsall, Ian R., Bowie, Andrew G., Beard, Philippa M., Unterholzner, Leonie
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5316833/
https://ncbi.nlm.nih.gov/pubmed/28194029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14392
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